This site is intended for healthcare professionals
Inflammatory Bowel Disease Learning Zone

Understanding Crohn’s disease

Read time: 20 mins
Last updated:14th Oct 2021
Published:14th Oct 2021

Get to grips with Crohn’s disease, an increasingly common and debilitating form of IBD.

  • Discover how early intervention could slow or even prevent disease progression
  • Identify common symptoms experienced by patients with this condition
  • Check out the global incidence with our insightful world map

Epidemiology

Prevalence and incidence

Crohn’s disease is an inflammatory bowel disease (IBD), characterised by chronic inflammation which can occur at any point along the gastrointestinal tract1. A growing body of evidence suggests that the prevalence and incidence of this debilitating condition is increasing globally, with some regional variation2–5.

Register for free access to this exclusive healthcare learning resource


Why sign up with Medthority?

Develop your knowledge with our disease and condition focused Learning Zones

Access content from credible sources, including expert-led commentary, videos, podcasts, and webinars as well as clinical trials, treatment information and guidelines 

Personalised dashboard providing updates and recommendations for content within your areas of interest

Pathophysiology

Pathogenesis

The pathogenesis of Crohn’s disease is not well understood, involving inflammatory processes of the intestinal tract, the origins of which are unknown19,20. This being said, it is thought that both the innate and adaptive immune responses play a role21. Indeed, massive infiltration of the mucosa by innate and adaptive immune cells is considered a key characteristic of active IBD in general22. This may be related to either overactivation of effector T cells or impaired T cell-mediated tolerance22. An abnormal and sustained host immune response is key to the development of IBD22.

Register for free access to this exclusive healthcare learning resource


Why sign up with Medthority?

Develop your knowledge with our disease and condition focused Learning Zones

Access content from credible sources, including expert-led commentary, videos, podcasts, and webinars as well as clinical trials, treatment information and guidelines 

Personalised dashboard providing updates and recommendations for content within your areas of interest

Treatment goals

Evolution of treatment goals and treat-to-target

Register for free access to this exclusive healthcare learning resource


Why sign up with Medthority?

Develop your knowledge with our disease and condition focused Learning Zones

Access content from credible sources, including expert-led commentary, videos, podcasts, and webinars as well as clinical trials, treatment information and guidelines 

Personalised dashboard providing updates and recommendations for content within your areas of interest

References

Register for free access to this exclusive healthcare learning resource


Why sign up with Medthority?

Develop your knowledge with our disease and condition focused Learning Zones

Access content from credible sources, including expert-led commentary, videos, podcasts, and webinars as well as clinical trials, treatment information and guidelines 

Personalised dashboard providing updates and recommendations for content within your areas of interest

Welcome: