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Guideline on the management of primary resistant and relapsed classical Hodgkin lymphoma

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Last updated:1st Jan 2014

Patients with Hodgkin lymphoma which is refractory to first-line therapy, or who relapse after achieving an initial remission, can often still be treated effectively with further ('salvage') chemotherapy, which may be consolidated with stem cell transplantation in suitable patients. This guideline discusses the issues relating to patients with relapsed/refractory Hodgkin lymphoma, specifically:
1. Predicting prognosis at relapse/progression
2. Approaches to salvage chemotherapy - available regimens, choosing between them, and assessing response
3. Autologous stem cell transplantation
4. Allogeneic stem cell transplantation
5. Role of radiotherapy

The treatment of patients with previously untreated Hodgkin lymphoma is addressed in a separate guideline.

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