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Read time: 17 mins
Last updated: 06 May 2020
Published: 01 Apr 2021

4.1 Therapeutic indications

In adults and adolescents over 16 years Flixotide Nebules can be used:

For prophylactic management of severe chronic asthma in patients requiring high dose inhaled or oral corticosteroid therapy. On introduction of inhaled fluticasone propionate many patients currently treated with oral corticosteroids may be able to reduce significantly, or eliminate, their oral dose.

Flixotide Nebules 2 mg/2 ml are not licensed for use in children under 16 years and therefore should not be used in this patient population. Current clinical data do not allow appropriate dosage recommendations to be made in this patient population.

Fluticasone propionate given by inhalation has a potent glucocorticoid anti-inflammatory action within the lungs. It reduces symptoms and exacerbations of asthma in patients previously treated with bronchodilators alone or with other prophylactic therapy. Relatively brief symptomatic episodes can generally be relieved by the use of fast-acting bronchodilators, but longer-lasting exacerbations require, in addition, the use of corticosteroid therapy as soon as possible to control the inflammation.

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Drugs appearing in this section are approved by UK Medicines & Healthcare Products Regulatory Agency (MHRA), & the European Medicines Agency (EMA).