4.1 Therapeutic indications
Co-trimoxazole should only be used where, in the judgement of the physician, the benefits of treatment outweigh any possible risks; consideration should be given to the use of a single effective antibacterial agent.
Co-trimoxazole is an antibacterial agent. Co-trimoxazole is effective in vitro against a wide range of gram-positive and gram-negative organisms. It is not active against Mycobacterium tuberculosis, mycoplasma or Treponema pallidum, Pseudomonas aeruginosa is usually insensitive.
Co-trimoxazole is indicated for the treatment of adults, adolescents and children from 6 years of age.
Co-trimoxazole is indicated for the treatment of the following infections when owing to sensitive organisms (see section 5.1):
• Treatment and prophylaxis (primary and secondary) of Pneumocytosis jiroveci pneumonitis in adults and children.
• Treatment and prophylaxis of toxoplasmosis
• Treatment of nocardoasis.
The following infections may be treated with co-trimoxazole where there is bacterial evidence of sensitivity to co-trimoxazole and good reason to prefer the combination of antibiotics in co-trimoxazole to a single antibiotic.
• Treatment of urinary tract infections
• Treatment of acute exacerbations of chronic bronchitis
• Treatment of acute otitis media in children
Consideration should be given to official guidance on the appropriate use of antibacterial agents.
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