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Drug information

Doxycycline

POM
Read time: 14 mins
Last updated: 06 May 2020
Published: 01 Apr 2021

4.1 Therapeutic indications

Doxycycline has been found clinically effective in the treatment of a variety of infectionscaused by susceptible strains of Gram-positive and Gram-negative bacteria and certain other micro-organisms.

Respiratory tractinfections

Pneumonia and other lower respiratory tract infections due to susceptible strains of Streptococcus pneumoniae, Haemophilusinfluenzae, Klebsiella pneumoniae and other organisms. Mycoplasma pneumoniae pneumonia. Treatment of chronic bronchitis, sinusitis.

Urinary tractinfections

Infections caused by susceptible strains of Klebsiella species, Enterobacter species. Escherichia coli, Streptococcus faecalis and otherorganisms.

Sexually transmitteddiseases

Infections due to Chlamydia trachomatis including uncomplicated urethral, endocervical or rectal infections. Non-gonococcal urethritis caused by Ureaplasma urealyticum (T-mycoplasma). Doxycycline is also indicated in chancroid, granuloma inguinale and lymphogranuloma venereum. Doxycycline is an alternative drug in the treatment of gonorrhoea andsyphilis.

Dermatologicalinfections

Acne vulgaris when antibiotic therapy is considerednecessary.

Since Doxycycline is a member of the tetracycline group of antibiotics, it may be expected to be useful in the treatment of infections which respond to other tetracyclines suchas:

Ophthalmicinfections

Due to susceptible strains of gonococci, staphylococci and Haemophilusinfluenzae. Doxycycline Capsules are indicated in the treatment of trachoma, although the infectious agent is not always eliminated, as judged byimmunofluorescence. Inclusion conjunctivitis may be treated with oral Doxycycline alone or in combination with topical agents.

Rickettsialinfections

Rocky Mountain spotted fever, typhus group, Q fever, Coxiella endocarditis and tickfevers.

Otherinfections

Psittacosis, cholera, bubonic plague, meliodosis, leptospirosis, other infections due to susceptible strains of Yersinia species, tularaemiaglanders, Brucella species (in combination with Streptomycin), Clostridiumspecies, Francisellatularensis and chloroquine-resistant falciparummalaria and acute intestinal amoebiasis (as an adjunct to amoebicides).

Doxycycline Capsules are indicated for prophylaxis in the following conditions: Scrub typhus, traveller's diarrhoea (enterotoxigenic Escherichia coli),leptospirosis.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

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Drug Licencing

Drugs appearing in this section are approved by UK Medicines & Healthcare Products Regulatory Agency (MHRA), & the European Medicines Agency (EMA).