4.1 Therapeutic indications
Mannitol 15% w/v is indicated for use as an osmotic diuretic in the following situations:
• Promotion of diuresis in the prevention and/or treatment of the oliguric phase of acute renal failure before irreversible oliguric renal failure becomes established.
• Reduction of intracranial pressure and cerebral oedema, when the blood-barrier is intact.
• Reduction of elevated intraocular pressure when it cannot be lowered by other means.
• Promotion of elimination of renally excreted toxic substances in poisoning.
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Drugs appearing in this section are approved by UK Medicines & Healthcare Products Regulatory Agency (MHRA), & the European Medicines Agency (EMA).