PH1 management
Management options for PH1 have traditionally included conservative measures and dual liver and kidney transplantation, but therapeutic approaches are evolving.
Management approaches for PH1 have traditionally included initial measures such as hyperhydration and intensive dialysis to clear oxalate and slow progressive decline in kidney function1,2. Liver transplantation, which replaces the site of faulty gene expression associated with oxalate overproduction, may provide a potential cure, although there are risks associated with this1,2. More recent developments include RNA interference (RNAi) therapy, which targets and prevents liver oxalate production, without the need for transplantation3. Current and potential future management approaches for PH1 are discussed below.
In this section
Children
Current and future treatment approaches in children
Adults
Reviewing the management strategies in adults
Adults seen in urology
Treatment approaches for adults seen in urology
PH1 management references
References cited within the Management section if the Primary hyperoxaluria type 1 Learning Zone.
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Date of preparation: March 2021 │ OXL-CEMEA-00011
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