I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus Late in Intensive Care Unit)

Acute renal failure is one of the most feared complications of septic shock and occurs in 51% of patients with these conditions. Mortality at 3 months ranges from 36% to 60%. To date, these exists no consensus regarding the optimal time to initiate hemodialysis. Retrospective and observational studies have suggested that early initiation of hemodialysis could help to improve prognosis in these patients. Therefore, we aim to investigate wether early initiation of hemodialysis (within 12 hours after a diagnosis of acute renal insufficiency at the "failure" stage according to the RIFLE Criteria), will reduce 90-day mortality as compared to deferred initiation of hemodialysis (48 to 60 hours after diagnosis), in intensive care unit (ICU) patients with septic shock who develop acute renal failure.