Fecal Microbiota Transplantation As a Potential Treatment for Parkinson's Disease

Brief Summary:
This pilot study aims to further explore the potential usage of Fecal microbiota transplantation in treating constipation and possibly also motor symptoms in Parkinson's disease (PD) patients, and to increase understanding of the potential relationship between the identities of intestinal microbial communities and PD.

Detailed Description:
Fecal microbiota transplantation (FMT) is a technique in which intestinal microbiota are transferred from a healthy donor to the patient, with as primary goal to introduce - or restore - a stable and 'healthy' microbial community in the gut.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms and Gastrointestinal dysfunction, in particular constipation, affects up to 80% of PD patients and may precede the onset of motor symptoms by years.

This study include one group of PD patients that will receive FMT. two other groups will serve as controls:
1. PD patients that will not receive FMT
2. healthy people who live with PD patients in the same house and share similar surrounding


Study Type: Interventional  (Clinical Trial)
Estimated Enrollment: 100 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Fecal Microbiota Transplantation As a Potential Treatment for Parkinson's Disease: A Pilot Study
Actual Study Start Date: August 19, 2015
Estimated Primary Completion Date: December 30, 2019
Estimated Study Completion Date: December 30, 2019

Arms:
- Experimental: PD patients that will receive FMT
- No Intervention: PD patients that will not receive FMT
- No Intervention: healthy people live with PD patients