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Clinical trial

Advantageous Predictors of Acute Coronary Syndromes Evaluation (APACE) Study

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Last updated:1st Apr 2006

The triage of patients with suspected acute coronary syndrome in the emergency room is a time-consuming diagnostic challenge. Therefore high sensitive early markers for myocardial damage are needed for more rapidly rule out of acute myocardial infarction (AMI) - especially for the first 3 to 4 hours after onset of chest pain in AMI ("troponin-blind" period).

Therefore we test the hypothesis that the use meticulous patient history and novel cardiac markers can provide a faster detection or exclusion of AMI in patients presenting with acute chest pain to the emergency department.

The prospective cohort study is designed to enrol 700 patients presenting with acute chest pain at rest within the last 12 hours to the emergency department. Several blood samples for detection of the new markers will be drawn and compared with the gold standard for the diagnosis of AMI (troponin T). All patients will be contacted by telephone at 6, 12 and 24 months to determine functional status, major adverse cardiac events (death, myocardial infarction, coronary artery bypass grafting, percutaneous coronary intervention), and the results of cardiac examination (stress test, coronary angiography) if performed.

Study Type: Observational
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Advantageous Predictors of Acute Coronary Syndromes Evaluation (APACE) Study
Estimated Enrollment: 6000
Study Start Date: April 2006
Estimated Study Completion Date: June 2018
Estimated Primary Completion Date: September 2017 (Final data collection date for primary outcome measure)

Category Value
Study start date 2006-04-01

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