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Clinical trial

A Study of Ruxolitinib in Pancreatic Cancer Patients

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Last updated:1st Apr 2014

To determine the efficacy, based upon overall survival, of ruxolitinib added to capecitabine for the treatment of metastatic pancreatic cancer.

Study Type: Interventional
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: A Randomized, Double-Blind, Phase 3 Study of the JAK 1/2 Inhibitor, Ruxolitinib or Placebo in Combination With Capecitabine in Subjects With Advanced or Metastatic Adenocarcinoma of the Pancreas Who Have Failed or Are Intolerant to First-Line Chemotherapy (The JANUS 2 Study)
Estimated Enrollment: 270
Study Start Date: April 2014
Estimated Study Completion Date: October 2017
Estimated Primary Completion Date: June 2017 (Final data collection date for primary outcome measure)

- Experimental:
Ruxolitinib plus capecitabine
- Active Comparator: Placebo plus capecitabine

Category Value
Study start date 2014-04-01

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