18F-fluoride (18F-NaF) PET for Identifying Coronary Atherosclerotic Plaques

The purpose of this study is to evaluate whether 18F-NaF (sodium fluoride) Positron Emission Tomography (PET) scans can be used to identify ruptured and high-risk plaque as compared to non-invasive coronary Computed Tomography Angiography (CTA) scans and high-definition intravascular ultrasound (IVUS).

In subsets of patients, 18F-NaF PET scans and CCTA will be repeated to assess scan-rescan reproducibility.


Study Type: Interventional
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: 18F-fluoride (18F-NaF) Positron Emission Tomography (PET) for Identification of Ruptured and High-Risk Coronary Atherosclerotic Plaques
Estimated Enrollment: 120
Study Start Date: November 2015
Estimated Primary Completion Date: October 2017 (Final data collection date for primary outcome measure)

Arms:
- Experimental: 18F-NaF PET and coronary CTA imaging